The development of iron regulated protein vaccines against pasteurellosis

An account of the application of emerging molecular techniques to the problem of developing new types of vaccines for this important disease.

Year of Publication2003

Pasteurellosis is a serious disease affecting sheep and cattle worldwide. The best means of control is believed to be through vaccination although up to recently the available vaccines have not been very effective. Research at Moredun Research Institute (MRI) into pasteurellosis caused by Mannheimia haemolytica and Pasteurella trehalosi demonstrated that immunity to infection could be stimulated by components of the bacterial cells which were preferentially expressed in response to low iron conditions. Second generation vaccines containing these iron regulated proteins (IRPs) were developed and tested in sheep and cattle disease models where they were shown to confer protection against infection. Subsequently vaccines based on IRPs have been developed as commercial products.

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